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    Ada1-1 transcriptional Adaptor 1-1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318991, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Ada1-1provided by FlyBase
    Official Full Name
    transcriptional Adaptor 1-1provided by FlyBase
    Primary source
    FLYBASE:FBgn0051865
    Locus tag
    Dmel_CG31865
    See related
    AllianceGenome:FB:FBgn0051865
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Ada1; ada1-1; BcDNA:RE30472; CG31865; dAda1; Dmel\CG31865
    Summary
    Predicted to enable transcription coactivator activity. Involved in histone H3 acetylation. Located in nucleus. Part of SAGA complex. Orthologous to human TADA1 (transcriptional adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Ada1-1 in Genome Data Viewer
    Location:
    33B5-33B5; 2-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11996809..11997965)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11996809..11997965)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene transcriptional Adaptor 1-2 Neighboring gene uncharacterized protein Neighboring gene Quetzalcoatl Neighboring gene uncharacterized protein Neighboring gene Nfs1 cysteine desulfurase Neighboring gene 3-hydroxyacyl-CoA dehydratase 1 Neighboring gene Rhodopsin 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adaptive impact of the chimeric gene Quetzalcoatl in Drosophila melanogaster. Rogers RL, et al. Proc Natl Acad Sci U S A, 2010 Jun 15. PMID 20534482, Free PMC Article
    2. Insights into SAGA function during gene expression. Rodríguez-Navarro S. EMBO Rep, 2009 Aug. PMID 19609321, Free PMC Article
    3. Microarray-based capture of novel expressed cell type-specific transfrags (CoNECT) to annotate tissue-specific transcription in Drosophila melanogaster. Hong X, et al. G3 (Bethesda), 2012 Aug. PMID 22908036, Free PMC Article
    4. The essential gene wda encodes a WD40 repeat subunit of Drosophila SAGA required for histone H3 acetylation. Guelman S, et al. Mol Cell Biol, 2006 Oct. PMID 16980620, Free PMC Article
    5. What do the structures of GCN5-containing complexes teach us about their function? Helmlinger D, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Feb. PMID 32739556

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAGA-type complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcriptional adaptor 1-1
    Names
    Ada1
    Ada1-1-PA
    Ada1-1-PB
    CG31865-PA
    CG31865-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11996809..11997965
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164984.3 → NP_723707.1  transcriptional adaptor 1-1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723707.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4XVG3, Q8IP99
      Related
      FBpp0079873
      Conserved Domains (1) summary
      pfam12767
      Location:10 → 74
      SAGA-Tad1; Transcriptional regulator of RNA polII, SAGA, subunit

    2. NM_001298929.1 → NP_001285858.1  transcriptional adaptor 1-1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285858.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4XVG3, Q8IP99
      Conserved Domains (1) summary
      pfam12767
      Location:10 → 74
      SAGA-Tad1; Transcriptional regulator of RNA polII, SAGA, subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGU1 Q8IGU1
    Q8IP99 Q8IP99

    Gene LinkOut

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