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    DCP2 Decapping protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39722, updated on 26-Apr-2024

    Summary

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    Official Symbol
    DCP2provided by FlyBase
    Official Full Name
    Decapping protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0036534
    Locus tag
    Dmel_CG6169
    See related
    AllianceGenome:FB:FBgn0036534
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD07107; CG6169; dcp2; Dcp2; DCp2p; dDcp; dDcp2; dDCP2; Dmel\CG6169; l(3)tb; LD07107
    Summary
    Enables actin filament binding activity and m7G(5')pppN diphosphatase activity. Involved in several processes, including negative regulation of gene expression; pole plasm oskar mRNA localization; and regulation of cytoplasmic mRNA processing body assembly. Located in P-body and pole plasm. Is expressed in several structures, including adult brain and ovary. Orthologous to human DCP2 (decapping mRNA 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    72A1-72A1; 3-43 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15818734..15826423, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15811834..15819523, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene flower Neighboring gene CKII-alpha subunit interactor-1 Neighboring gene diablo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genome-wide RNAi screen reveals that mRNA decapping restricts bunyaviral replication by limiting the pools of Dcp2-accessible targets for cap-snatching. Hopkins KC, et al. Genes Dev, 2013 Jul 1. PMID 23824541, Free PMC Article
    2. The mRNA decapping protein 2 (DCP2) is a major regulator of developmental events in Drosophila-insights from expression paradigms. Kunar R, et al. Cell Tissue Res, 2021 Nov. PMID 34536141
    3. The C-terminal region of Ge-1 presents conserved structural features required for P-body localization. Jinek M, et al. RNA, 2008 Oct. PMID 18755833, Free PMC Article
    4. Unique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs. Arvola RM, et al. Nucleic Acids Res, 2020 Feb 28. PMID 31863588, Free PMC Article
    5. Dbo/Henji Modulates Synaptic dPAK to Gate Glutamate Receptor Abundance and Postsynaptic Response. Wang M, et al. PLoS Genet, 2016 Oct. PMID 27736876, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mRNA decapping protein 2 (DCP2) is a major regulator of developmental events in Drosophila-insights from expression paradigms.
      Title: The mRNA decapping protein 2 (DCP2) is a major regulator of developmental events in Drosophila-insights from expression paradigms.
    2. A Forward Genetic Approach to Mapping a P-Element Second Site Mutation Identifies DCP2 as a Novel Tumor Suppressor in Drosophila melanogaster.
      Title: A Forward Genetic Approach to Mapping a P-Element Second Site Mutation Identifies DCP2 as a Novel Tumor Suppressor in Drosophila melanogaster.
    3. Drosophila decapping protein 2 modulates the formation of cortical F-actin for germ plasm assembly.
      Title: Drosophila decapping protein 2 modulates the formation of cortical F-actin for germ plasm assembly.
    4. the catalytic activity of Pop2 deadenylase is important for Pumilio RD activity. Further, we show that the Pumilio RDs directly bind to the CNOT complex. We also report that the decapping enzyme, Dcp2, participates in repression by the N-terminus of Pumilio. These results support a model wherein Pumilio utilizes CNOT deadenylase and decapping complexes to accelerate destruction of target mRNAs.
      Title: Unique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs.
    5. down-regulation of Dcp2 mediates chronic nicotine-exposure-induced locomotor hyperactivity in Drosophila
      Title: Down-regulation of Decapping Protein 2 mediates chronic nicotine exposure-induced locomotor hyperactivity in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cortical actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in miRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pole plasm oskar mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytoplasmic mRNA processing body assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pole plasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    decapping protein 2
    Names
    CG6169-PA
    CG6169-PB
    CG6169-PD
    CG6169-PE
    DCP2-PA
    DCP2-PB
    DCP2-PD
    DCP2-PE
    lethal (3) tumorous brain
    NP_001014585.1
    NP_001246776.1
    NP_648805.2
    NP_730074.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15818734..15826423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259847.2 → NP_001246776.1  decapping protein 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246776.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U127
      Conserved Domains (2) summary
      cd03672
      Location:310 → 459
      Dcp2p; mRNA decapping enzyme 2 (Dcp2p), the catalytic subunit, and Dcp1p are the two components of the decapping enzyme complex. Decapping is a key step in both general and nonsense-mediated 5'->3' mRNA-decay pathways. Dcp2p contains an all-alpha helical ...
      pfam05026
      Location:212 → 307
      DCP2; Dcp2, box A domain

    2. NM_168634.5 → NP_730074.2  decapping protein 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730074.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NM7, Q8T3N6
      Conserved Domains (2) summary
      cd03672
      Location:83 → 232
      Dcp2p; mRNA decapping enzyme 2 (Dcp2p), the catalytic subunit, and Dcp1p are the two components of the decapping enzyme complex. Decapping is a key step in both general and nonsense-mediated 5'->3' mRNA-decay pathways. Dcp2p contains an all-alpha helical ...
      pfam05026
      Location:2 → 80
      DCP2; Dcp2, box A domain

    3. NM_140548.5 → NP_648805.2  decapping protein 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648805.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUU4
      Conserved Domains (2) summary
      cd03672
      Location:310 → 459
      Dcp2p; mRNA decapping enzyme 2 (Dcp2p), the catalytic subunit, and Dcp1p are the two components of the decapping enzyme complex. Decapping is a key step in both general and nonsense-mediated 5'->3' mRNA-decay pathways. Dcp2p contains an all-alpha helical ...
      pfam05026
      Location:212 → 307
      DCP2; Dcp2, box A domain

    4. NM_001014585.2 → NP_001014585.1  decapping protein 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014585.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NM7, Q8T3N6
      Conserved Domains (2) summary
      cd03672
      Location:83 → 232
      Dcp2p; mRNA decapping enzyme 2 (Dcp2p), the catalytic subunit, and Dcp1p are the two components of the decapping enzyme complex. Decapping is a key step in both general and nonsense-mediated 5'->3' mRNA-decay pathways. Dcp2p contains an all-alpha helical ...
      pfam05026
      Location:2 → 80
      DCP2; Dcp2, box A domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U127 Q5U127
    Q86NM7 Q86NM7
    Q8T3N6 Q8T3N6
    Q9VUU4 Q9VUU4

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