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Molecular mechanism of specific HLA-A mRNA recognition by the RNA-binding-protein hMEX3B to promote tumor ... - Nature.com
May 03, 2024 - 11:11 PM - by nmrlearner
nmrlearner's Avatar Molecular mechanism of specific HLA-A mRNA recognition by the RNA-binding-protein hMEX3B to promote tumor ... - Nature.com

Molecular mechanism of specific HLA-A mRNA recognition by the RNA-binding-protein hMEX3B to promote tumor ... Nature.com Read here
0 Replies | 10 Views
NMR Investigation of Structures of G-protein Coupled Receptor Folding Intermediates - ScienceDirect.com
May 02, 2024 - 12:40 PM - by nmrlearner
nmrlearner's Avatar NMR Investigation of Structures of G-protein Coupled Receptor Folding Intermediates - ScienceDirect.com

NMR Investigation of Structures of G-protein Coupled Receptor Folding Intermediates ScienceDirect.com Read here
0 Replies | 13 Views
A post-translational modification of human Norovirus capsid protein attenuates glycan binding - Nature.com
May 02, 2024 - 12:40 AM - by nmrlearner
nmrlearner's Avatar A post-translational modification of human Norovirus capsid protein attenuates glycan binding - Nature.com

A post-translational modification of human Norovirus capsid protein attenuates glycan binding Nature.com Read here
0 Replies | 14 Views
Water mobility and microstructure of acidified milk model gels with added whey protein ingredients - ScienceDirect.com
May 01, 2024 - 12:40 PM - by nmrlearner
nmrlearner's Avatar Water mobility and microstructure of acidified milk model gels with added whey protein ingredients - ScienceDirect.com

Water mobility and microstructure of acidified milk model gels with added whey protein ingredients ScienceDirect.com Read here
0 Replies | 22 Views
[NMR paper] Genetic Encoding of Fluoro-l-tryptophans for Site-Specific Detection of Conformational Heterogeneity in Proteins by NMR Spectroscopy
Apr 30, 2024 - 10:50 PM - by nmrlearner
nmrlearner's Avatar Genetic Encoding of Fluoro-l-tryptophans for Site-Specific Detection of Conformational Heterogeneity in Proteins by NMR Spectroscopy

The substitution of a single hydrogen atom in a protein by fluorine yields a site-specific probe for sensitive detection by ^(19)F nuclear magnetic resonance (NMR) spectroscopy, where the absence of background signal from the protein facilitates the detection of minor conformational species. We developed genetic encoding systems for the site-selective incorporation of 4-fluorotryptophan, 5-fluorotryptophan, 6-fluorotryptophan, and 7-fluorotryptophan in response to an amber stop codon and used...

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0 Replies | 282 Views
Detection of low density lipoprotein particle fusion by proton nuclear magnetic resonance spectroscopy - ScienceDirect.com
Apr 29, 2024 - 10:55 PM - by nmrlearner
nmrlearner's Avatar Detection of low density lipoprotein particle fusion by proton nuclear magnetic resonance spectroscopy ScienceDirect.com
Detection of low density lipoprotein particle fusion by proton nuclear magnetic resonance spectroscopy - ScienceDirect.com
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0 Replies | 27 Views
[NMR paper] Milligram-Scale Assembly and NMR Fingerprint of Tau Fibrils Adopting the Alzheimer's Disease Fold
Apr 29, 2024 - 9:50 AM - by nmrlearner
nmrlearner's Avatar Milligram-Scale Assembly and NMR Fingerprint of Tau Fibrils Adopting the Alzheimer's Disease Fold

In the Alzheimer's disease (AD) brain, the microtubule-associated protein tau aggregates into paired helical filaments (PHFs) in which each protofilament has a C-shaped conformation. In vitro assembly of tau fibrils adopting this fold is highly valuable for both fundamental and applied studies of AD without requiring patient-brain extracted fibrils. To date, reported methods for forming AD-fold tau fibrils have been irreproducible and sensitive to subtle variations in fibrillization conditions....

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0 Replies | 136 Views
[NMR paper] NMR insights into beta-Lactamase activity of UVI31+ Protein from Chlamydomonas reinhardtii
Apr 28, 2024 - 9:50 PM - by nmrlearner
nmrlearner's Avatar NMR insights into beta-Lactamase activity of UVI31+ Protein from Chlamydomonas reinhardtii

?-Lactamases (EC 3.5.2.6) confer resistance against ?-lactam group-containing antibiotics in bacteria and higher eukaryotes, including humans. Pathogenic bacterial resistance against ?-lactam antibiotics is a primary concern for potential therapeutic developments and drug targets. Here, we report putative ?-lactamase activity, sulbactam binding (a ?-lactam analogue) in the low ?M affinity range, and site-specific interaction studies of a 14 kDa UV- and dark-inducible protein (abbreviated as...

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0 Replies | 67 Views
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