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    Uev1A Ubiquitin-conjugating enzyme variant 1A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38613, updated on 5-May-2024

    Summary

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    Official Symbol
    Uev1Aprovided by FlyBase
    Official Full Name
    Ubiquitin-conjugating enzyme variant 1Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035601
    Locus tag
    Dmel_CG10640
    See related
    AllianceGenome:FB:FBgn0035601
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10640; Dmel\CG10640; DmUEV; DmUev1a; dUev1A; dUEV1a; dUEV1A; UEV; uev1a; Uev1a; UEV1a; UEV1A
    Summary
    Enables ubiquitin conjugating enzyme binding activity. Involved in peptidoglycan recognition protein signaling pathway; positive regulation of signal transduction; and protein polyubiquitination. Part of UBC13-UEV1A complex. Is expressed in several structures, including adult heart; anterior endoderm anlage; gastrula embryo; germline cell; and gonad. Orthologous to human UBE2V2 (ubiquitin conjugating enzyme E2 V2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    64C13-64C13; 3-13 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5362884..5366225, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5355984..5359325, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Kinesin-like protein at 64D Neighboring gene Cytochrome c1 Neighboring gene membrin Neighboring gene Prefoldin 4 Neighboring gene long non-coding RNA:CR44515

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila Uev1a is dually required for Ben-dependent DNA-damage response and fly mobility.
      Title: Drosophila Uev1a is dually required for Ben-dependent DNA-damage response and fly mobility.
    2. data indicate that dUev1a encodes an essential component of the evolutionary conserved TNF-JNK signaling pathway that modulates tumor progression and cell death in metazoan
      Title: dUev1a modulates TNF-JNK mediated tumor progression and cell death in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of positive regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of positive regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of tumor necrosis factor-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in postreplication repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of UBC13-UEV1A complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquitin-conjugating enzyme
    Names
    CG10640-PA
    CG10640-PB
    CG10640-PC
    Uev1A-PA
    Uev1A-PB
    Uev1A-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5362884..5366225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168117.3 → NP_729062.1  Ubiquitin-conjugating enzyme variant 1A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729062.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQ53
      Related
      FBpp0076860
      Conserved Domains (1) summary
      smart00212
      Location:2 → 100
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    2. NM_001300011.1 → NP_001286940.1  Ubiquitin-conjugating enzyme variant 1A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286940.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGH9, Q9VRL1
      Conserved Domains (1) summary
      smart00212
      Location:16 → 142
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    3. NM_139702.4 → NP_647959.1  Ubiquitin-conjugating enzyme variant 1A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647959.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGH9, Q9VRL1
      Related
      FBpp0076859
      Conserved Domains (1) summary
      smart00212
      Location:16 → 142
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGH9 Q8IGH9
    Q8IQ53 Q8IQ53
    Q9VRL1 Q9VRL1

    Gene LinkOut

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